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Researchers
found that Flavay™ worked as well as the commonly prescribed stimulant
medications, including Ritalin, on thirty children and adults diagnosed
with attention disorders. (115) The difference is that Flavay™ nourishes the brain...
Flavay™
is totally safe to use; a 100% non-toxic and natural—but powerfully
effective—nutritional supplement. Flavay™ is a highly specialized,
nutritional complex of pairs and triples of a specific molecule called
"flavan-3-ol," isolated from natural extracts, that has been
extensively tested and examined clinically for biological antioxidant
protection, collagen strengthening, tissue rebuilding, and other health
producing outcomes.
Manufactured and used in France since 1950 for circulatory
problems, inflammation and allergies, a more recent use of Flavay™
has arisen among people suffering from a lack of concentration and attention.
It is said to have begun quite accidentally when people took the product
for another purpose, such as allergies, and noticed an improvement in
concentration and mental focus—the classic symptoms of attention
deficit.
Scientifically, how could this possibly be true? How could
molecules extracted from mundane vegetal sources have a profound influence
on the brain? According to scientific research, there are a number of
mechanisms of action.
Many decades of studies have established that Flavay™ improves
circulation, including microcirculation in the brain. Flavay™ is one of
the few dietary antioxidants that readily crosses the blood-brain barrier
to protect brain cells. The blood-brain barrier protects the brain from
compounds that normally circulate in the blood. Brain cells are very sensitive
to some compounds, even though they may not damage other cells in the
body or even be needed by other cells. In laboratory experiments in which
blood is rapidly injected into brain blood vessels, dramatically increasing
the blood pressure within those vessels for a brief time, Flavay™ shows
a significant protective effect. (3, 4, 1)
| Research demonstrates Flavay’s™
ability to help regulate nitric oxide—one of the newest neurotransmitters
to demand the scientific spotlight as it modulates communication between
brain cells and is thereby deeply involved in concentration, learning
and memory; and helps coordinate activity between the brain and immune
system. |
Flavay’s antioxidant protection of brain cells is significant as recent
studies have established a connection between free radical damage and cognitive
impairment. Research demonstrates that Flavay™ helps regulate nitric oxide:
a colorless gas produced by many different cells in the body: from endothelial
cells on the walls of the arteries to the neurons in the brain to the disease-fighting
cells of the immune system. Nitric oxide modulates communication between
brain cells and is thereby deeply involved in concentration, learning and
memory. And, by controlling the muscular tone of blood vessels, nitric oxide
regulates circulation and normalizes blood flow. As long as nitric oxide
is produced in the right amount, it is beneficial to the body. Overproduction
of nitric oxide, however, promotes production of more free radicals in the
brain, which can hamper mental function and cause memory loss and brain
aging. Thus, Flavay’s ability to help maintain the optimal level of
nitric oxide profoundly influences brain (and immune) functions. (2,
95)
There is also evidence that Flavay™ may help the body to regulate enzymes
which control the crucial neurotransmitters dopamine and norepinephrine,
chemicals that carry messages among brain cells and are involved in excitatory
responses. Flavay’s ability to support healthy blood flow to the
brain is also important to brain function. Researchers have shown that
decreased blood flow to the brain plays a major role in age-related brain
disorders. Flavay™ may also help deliver other
nutrients to the brain, such as zinc and selenium, which are essential
to normal brain function, according to recent research. Preliminary studies
have confirmed what many users of this remarkable complex have experienced:
striking benefits in improved concentration and mental focus, the classic
symptoms of attention deficit disorder. (115,
3, 4)
A preliminary study by a psychologist in Tulsa, Oklahoma,
who specializes in treating attention deficit disorder, found striking
benefits from these naturally-derived molecules, known as Flavay™.
The researchers found that it worked just as well as the commonly prescribed
stimulant medications, including Ritalin, on thirty children and adults
diagnosed with ADD. The subjects were given a battery of computerized
and behavior tests to judge their attention, concentration, and other
important factors in ADD under various circumstances: when they were either
on or off their usual stimulant medications, or on Flavay™ alone. When
they were off their medications, their ADD deteriorated. On their medications,
they were much improved. But when they took daily doses of Flavay™, their
scores and behavior were just as improved as when they took stimulant
drugs. Many of the subjects also had other positive effects. (115)
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"[A] method for preventing and fighting the
harmful biological effects of free radicals ... namely cerebral
involution, hypoxia following atherosclerosis, cardiac or cerebral
infarction, tumour promotion, inflammation, ischaemia, alterations
of the synovial liquid, collagen degradation, among others"
—U.S. PATENT NO. 4,698,360, Dr. Jack Masquelier.
|
This nontoxic, water soluble nutrient holds promise as an
alternative to Ritalin. Many children with ADD have found this substance
effective to decrease their symptoms by normalizing brain function. It
seems to improve memory by improving circulation to the brain. Free radicals
reprogram DNA and have been implicated in more than sixty diseases. Flavay™
has been shown to help in inflammation of the joints and other tissues,
as well as improve functioning of the circulatory, nervous and immune
systems. (131, 1)
Flavay™ Supports The Brain-Immune
Connection
|
Flavay™ can profoundly influence both the
brain and the immune system by preventing free radical damage to
macrophages, a type of white blood cell that generates nitric oxide
to destroy bacteria, viruses and host parasites.
|
Top research institutions worldwide now understand that
there is a two-way chemical dialog between the brain and the immune system.
Each can influence the other directly. There is an ongoing chemical dialog
between the brain and the immune system, a connection that depends on
two languages: the neurotransmitters of the brain, and the immunotransmitters
of the immune system. (2)
Flavay™ supports your immune system in several important ways. First,
by recycling the activity of vitamins C and E—key players in the
body's immune system—Flavay™ gives the body more ammunition to fight
infection. Second, research demonstrates that Flavay™ prevents free radical
damage to macrophages, a type of white blood cell that generates nitric
oxide to destroy bacteria, viruses, and host parasites. (4,
5, 2)
As long as nitric oxide is produced in the right amount, it is beneficial
to the body; nitric oxide fights infection, kills tumor cells, and promotes
wound healing. But when nitric oxide is produced in excess, it throws
the brain-immune connection off kilter and causes some of the brain's
worst free radical damage. Over the past decade, scientists have shown
that the production of nitric oxide through the combination of immune
and nervous system activity (often sparked by an infection, exposure to
a toxin, or as part of the aging process) plays a key role in the development
of neurological diseases. Thus, Flavay’s ability to help regulate
nitric oxide can profoundly benefit the body’s immune and brain functions.
(2)
Flavay Plus™
Adds Synergistic Help
for Brain Function, Attention & Acuity
|
Flavay Plus™ is a synergistic blend of Flavay™
with the other antioxidants and phytonutrients; formulated to normalize
brain and immune functions.
|
Flavay Plus™ uses a synergistic blend
of Flavay™ with antioxidant vitamins, minerals and other phytonutrients
to best take advantage of the dynamic interplay among the key antioxidants
and their co-factor nutrients.
Phosphatidyl serine: Flavay
Plus™ is formulated with phosphatidyl serine (Leci-PS™),
a complex of amino and fatty acids extracted from soy lecithin, which
has proven to be a safe, potentially effective therapeutic agent in treating
memory deficit disorders and is an often-used supplement for attention
deficit disorders. Phosphatidyl serine has been the subject of many human
clinical trials regarding memory loss, mood, cognitive performance, learning
ability and stress. Many studies show that phosphatidyl serine can optimize
cognition. In the most famous human study, researchers gave 300 mg of
phosphatidyl serine a day for 12 weeks to 149 subjects over 50. Various
memory and learning tests were administered before and after. The results
showed that phosphatidyl serine managed to raise cognitive performance
to the levels typical for as much as 12 years younger. (26,
28)
In a study where a group of 27 ADHD children took 200 to 300 mg of phosphatidyl
serine daily for four months, researchers found that 25 children exhibited
improvement in learning capacity and behavior; and the researchers noted
that there were no adverse affects.
This substance also has the potential to stimulate the brain to produce
dopamine. Published, double-blind research shows that phosphatidyl serine
can also be helpful for depression.
Phosphatidyl serine is a phospholipid that is vital to brain cell structure
and function. Phospholipids are molecules containing both amino and fatty
acid components, which are found in every cell membrane in our bodies.
Phosphatidyl serine plays an important role in our neurotransmitter systems,
in metabolism levels of the brain, and in maintaining nerve connections
in the brain. It appears to help reestablish the normal down-regulation
of cortisol secretion that is increased in chronically stressed individuals,
and its benefit in dementia and depression may relate to improved brain
cell membrane fluidity. In the clinical studies, phosphatidyl serine (100
mg three times daily) has been shown to improve the mood and mental function
in those with Parkinson’s disease. (26,
27, 32, 33)
Scientific studies have demonstrated that phosphatidyl serine supplementation
can increase the output of acetylcholine, the neurotransmitter so important
to memory. Clinical trials with elderly patients suffering from memory
deficit disorders have shown that adding phosphatidyl serine to the daily
diet improved the ability of these patients to think and decreased behavioral
disturbances. In other studies, phosphatidyl serine also improved the
performance of patients with age-associated memory impairment, a disorder
affecting millions of Americans each year. (32)
Flavay Plus™ Provides Synergistic
Help for Coping With Stress
Research has shown that phosphatidyl serine works to keep the brain’s
processes within normal limits, raising them when they are low and lowering
them when they are high. So phosphatidyl serine boosts the weak stress
response in the elderly person and calms down exaggerated stress in the
healthy young person. Both physical and mental stressful conditions cause
stress hormones to be released into circulation, even in the young and
healthy. Phosphatidyl serine given to athletes prior to starting exercise
produced an impressive degree of down-regulation of the stress hormones.
Phosphatidyl serine may have the capacity to “normalize” the
stress-induced activation of the hypothalamic-pituitary-adrenal axis.
In a double-blind, placebo-controlled study conducted in Italy, phosphatidyl
serine lowered stress hormone (cortisol) production by 30 percent. (31)
Flavay Plus™
is a synergistic blend of phosphatidyl serine with Flavay™
and other antioxidants and
B vitamins because researchers show that phosphatidyl serine "works
with other nutrients such as the B vitamins and antioxidants to
ensure smooth and efficient functioning of all the organs."
(150) |
Two more recent placebo controlled studies confirmed the earlier double-blind
trials; young, university students experienced significantly less stress
from tests when they took phosphatidyl serine (300 mg daily for 30 days),
they stayed more clear-headed and composed, and kept a more stable mood.
(148, 149)
Altogether, this research shows that Flavay
Plus™ can help young people confront the stressful challenges
of living in today's world.
Ginkgo biloba leaf: Flavay Plus™
also includes standardized ginkgo biloba leaf extract, primarily known
as a brain booster. In Germany and France, ginkgo biloba extract is commonly
prescribed for mental problems that are often caused by poor circulation
to the brain, such as difficulty concentrating, poor memory, confusion,
depression, and anxiety. There have been numerous European studies conducted
on ginkgo biloba extract and many have reported positive effects in terms
of memory and acuity. Recently, the New York Institute for Medical Research
conducted a double-blind, placebo-controlled study using ginkgo biloba
extract on patients suffering from dementia (caused by either stroke or
Alzheimer’s disease), with positive results. This is significant
because there are few drugs that have any impact at all on cases of dementia.
And, the study was published in a mainstream medical journal. (34)
Vitamin A (Beta-carotene and
cartenoids):
Flavay Plus™ contains the preferred form of Vitamin A, beta-carotene
(Betatene™). Beta-carotene is converted by the body into vitamin
A only as the body needs it and what isn't converted remains as a powerful
antioxidant, shown to be a cancer preventative, shown to strengthen the
immune system and benefit the eyes and cardiovascular system. The beta-carotene
in Flavay Plus™ is the highest quality, full-spectrum, patented Betatene™,
a complete array of plant-derived, antioxidant cartenoids: beta-carotene,
alpha-carotene, cryptoxanthin, zeaxanthin, lutein, and lycopene. (9,
6)
B-Vitamins: Flavay Plus™ is also
formulated with many B-vitamins, which are an important requirement of
the brain’s diet as they help form neurotransmitters (the chemical
messengers of the nervous system). Pyridoxal phosphate, a vitamin B-6
member, is pivotal in the synthesis of the neurotransmitters serotonin,
dopamine and gamma-amino butyric acid (GABA). For people who are over
stimulated, GABA induces a balancing relaxation. Some people with anxiety,
panic disorders, and depression may not manufacture sufficient levels
of GABA. (38, 39, 40, 41, 42, 43, 44)
Some nutrient deficiencies can produce symptoms that are familiar as
symptoms of hyperactivity and learning disorders. A deficiency of thiamin
(vitamin B-1), for example, may produce irritability, nervousness and
even increased sensitivity to noise. (45)
Some neurological childhood conditions appear to be connected to the
B-vitamins. A study conducted at Saint Joseph Hospital in Pennsylvania
found low serotonin (a neurotransmitter involved with mood) levels in
hyperactive children. The researchers gave some of the subjects vitamin
B-6 and observed their serotonin levels rise appreciably. Also, research
suggests that a deficiency of vitamins B-2 and B-6 play a primary role
in the cause of emotional disorders. (39, 43)
Vitamin B-12 deficiency can mimic Alzheimer’s disease: vitamin B-12
deficiency may cause fatigue, headaches, heart and nervous system disturbances
such as numbness and tingling of the arms or legs, depression, mental
confusion, and memory deficits. (9)
Vitamin C: Flavay Plus™ also contains
vitamin C: water-soluble, a potent free radical scavenger, recycles vitamin
E, plays a primary role in the formation of collagen, essential for vascular
health and a strong immune system. Controlled studies prove the contribution
of vitamin C in the manufacture of white blood cells and interferon. (6,
7, 8, 9, 95)
Flavay Plus™ uses Ester-C™, a patented, revolutionary form
of vitamin C that gets into the blood stream faster than ordinary vitamin
C, in larger amounts with less waste, stays in the body longer, and is
used more efficiently by cells and connective tissues. Ester-C™
is also buffered and stomach-friendly.
It's also important to note that Flavay™
dramatically extends the activity of vitamin C in the body.
Vitamin E: The body’s principal
fat-soluble antioxidant. Much of the body’s free radical damage occurs
in fats and in fatty membranes of cells—exactly where vitamin E protects
the body. (6, 7, 8, 9, 95)
Selenium:
Flavay
Plus™ includes selenium, as it is necessary for the body’s
production of glutathione (an antioxidant produced by the body which protects
the brain and nerve tissue from the harmful effects of free radicals)
and thioredoxin reductase which recycles vitamin C. Selenium also has
a synergistic effect with vitamin E, which means that the two combined
are more powerful than either alone. Many Americans do not consume even
the small RDA of selenium in their diet. (6,
7, 8, 9)
Zinc: Flavay Plus™ also includes
zinc because a number of studies are pointing to an association between
zinc deficiency and ADHD. One such 1996 study, published in the Journal
of Child Psychology and Psychiatry, revealed a statistically significant
correlation between zinc and fatty acids, in that both were decreased
in children with ADHD. In another study, conducted at Ohio State University,
investigators found a relationship between zinc deficiency and response
to stimulant therapy among people with ADHD. Basically, this study showed
that children diagnosed with ADHD may be zinc deficient, and that this
deficiency may result in their poor response to stimulant therapy. (2)
An essential mineral, zinc has many important effects on the brain and
immune system, including neurotransmitter production and enzyme functioning.
Zinc is a necessary part of the body’s production of DHA and a constituent
of many vital enzymes, including superoxide dismutase (SOD), which is
a critical cellular antioxidant enzyme that is responsible for mopping
up peroxynitrate, the highly toxic free radical produced in abundance
in the normal course of immune system battles (as in viral or bacterial
infections) and plays a powerful role in immune system inflammation. Together
with the B vitamins, zinc assists in the utilization of insulin and glucose.
There is a growing body of evidence to indicate that zinc is needed for
the proper maintenance of vitamin E levels in the blood and aids in the
absorption of vitamin A. Other important functions of zinc include the
promotion of glandular and reproductive health; and there is strong evidence
that zinc is required for the synthesis of the nucleic acids RNA and DNA,
which are essential for cell repair and cell growth. Studies have found
large percentages of apparently healthy children to be deficient in zinc.
There is evidence that zinc levels fall after physical and mental stress.
Flavay Plus™ uses zinc orotate, a high-quality, highly bioavailable
form of zinc. (6, 7, 8, 9)
Flavay Plus™ utilizes the dynamic
interplay between these nutrients and their co-factors in order to provide
you and your family with the best that nutritional science has to offer
in a convenient, cost effective capsule.
Proven Safety of Flavay™
After more than 50 years of human use, no adverse effects have been observed.
Furthermore, intensive biological, toxicological, pharmacological and analytical
research was conducted for the purpose of registering it as a medicine in France
and other countries in Europe. In one study, daily doses of up to 35,000 mg
for six months were determined to cause no adverse effects. Flavay™ was
also clinically tested, in particular for all sorts of symptoms related to venolymphatic
insufficiencies (strenghthening veins, improving circulation and reducing edema
and inflammations). The spin-off is a goldmine of data: The rigorous testing
to meet the standards required by the health ministries of France, Germany and
other European countries demonstrate that Flavay™ is highly bioavailable,
nontoxic, nonallergenic, noncarcinogenic, nonmutagenic, will not cause birth
defects, and is completely safe. (3, 4, 109-114)
Dr. Masquelier’s unequaled manufacturing process has been conducted
for half a century at the very same facilities in France, and under the
control of French Pharmaceutical inspection. These time-proven standards
serve as a reliable assurance of the quality, consistency, bioavailability
and safety of Flavay™.
Who can take Flavay™?
Everyone, from the very young to elderly. Flavay™ has no known contraindications
(conditions under which it should not be used). Flavay™ is completely safe
and nontoxic. In fact, clinical trials have been conducted in which pregnant
women (troubled by varicose veins and other circulatory problems in the
legs) safely used Flavay™. (3)
Safety of Flavay Plus™
The essential vitamins and minerals in Flavay Plus™ are naturally-derived and completely safe. Flavay Plus™ includes
phosphatidyl serine, derived from soy lecithin, which has been proven
safe in standard toxicology tests. From the large number of human studies
conducted, phosphatidyl serine has developed a flawless safety record
and proven compatible with a wide array of medications. (26)
Why Trust Flavay™
Consumers need to know that the marketplace is full of imitations, various
“extracts” and derivative forms of Dr. Masquelier’s scientifically
proven and patented complex. Unfortunately, many have even used Dr. Masquelier’s
name and research in unauthorized ways to promote illegitimate products.
Flavay is the name you can trust for the precisely defined active polyphenol
complex patented and perfected by the inventor, Dr. Jack Masquelier, validated
by the French Ministry of Health and documented by a library of research
consisting of many patents and hundreds of scientific papers, articles,
doctorate theses, lectures and presentations. For quality, consistency,
bioavailablity and safety, consumers may rely upon Flavay™.
Flavay™ and Flavay Plus™
for Concentration and Attention
Altogether, this research shows that Flavay™
and Flavay Plus™ can help people of
all ages confront the stressful challenges of living in today's world
with improved concentration and attention—providing you and your
family with the best that nutritional science has to offer in convenient,
cost effective capsules.
CLICK
HERE TO SEE WHAT ACTUAL CUSTOMERS ARE SAYING 
Statements made herein have not been
evaluated by the Food and Drug Administration. These products are not intended
to diagnose, treat, cure or prevent any disease.
|
REFERENCES:
Top 
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1. Masquelier, J. Plant extract with
a proanthocyanidins content as a therapeutic agent having radical scavenging
effect and use thereof. U.S. Patent No. 4,698,360, 1987.
2. Lombard, J., (board certified neurologist), Germano, C. The Brain Wellness
Plan - Breakthrough Medical, Nutritional and Immune-Boosting Therapies to
Prevent and Treat Depression, Alzheimer's Disease, Chronic Fatigue Syndrome,
Attention Deficit Disorder, Multiple Sclerosis, Parkinson's Disease, Lou
Gehrig's Disease. Kensington Pub. Corp., 1998.
3. Masquelier, J. A lifetime devoted to OPC and Pycnogenols. Alfa Omega
Editrice, Pub., 1996.
4. Schwitters, B., Masquelier, J. OPC in practice. Alfa Omega Editrice,
Publishers, 1995.
5. Kilham, C., Masquelier, J. OPC: The miracle antioxidant. Keats Publishing,
Inc., 1997.
6. Mindell, E., et al. Earl Mindell’s vitamin bible for the 21st century.
Warner Books, Inc., 1999.
7. Passwater, R.A. The antioxidants: the nutrients that guard your body.
Keats Publishing, Inc., 1985.
8. Barilla, J. et al. The nutrition superbook: volume 1: the antioxidants.
Keats Publishing, Inc., 1995.
9. Lieberman, S., et al. The real vitamin & mineral book: going beyond
the RDA. Avery Pub., 1990.
10. ___. Inadequate intake of vitamins, particularly B-1, can result in
mental illness. Clin. Neuro, 8 (Jul.--Sep. 1985):286-293.
11. ___. Carpal tunnel syndrome treated with riboflavin and pyridoxine.
Proceedings of the Nat. Acad. of Sc. 81 (Nov. 1984):7076-8.
12. ___. High calorie diets with disproportionately low intakes of vitamins
and minerals may be the source of widespread marginal malnutrition. Journ
of the Amer Col of Nut, 7 (1988):61-67.
13. Facino RM, et al. Free radical scavenging action and anti-enzyme activities
of procyanidines from Vitis vinifera. A mechanism for their capillary protective
action. Arzneimittelforschung, 44: 592-601, 1994.
14. Kuttan R, et al. Collagen treated with catechin becomes resistant to
the action of mammalian collagenase. Experientia, 37: 221-223, 1981.
15. Masquelier, J., et al. Stabilization du collagene par les oligomeres
procyanidoliques. Acta Therapeutica, 7:101-105, 1981.
16. Masquelier, J. Aspects pharmacologiques nouveaux de certains
flavonoides.
A Vie Medical 12:1969.
16. Laparra, J., et al. Etude pharmaco-cinetique des oligomers procyandoliques
totaux du raisin. Acta Therapeutica, 4, 1978.
18. Laparra, J., et al. Etude pharmacocinetique des oligomeres
flavonoliques.
Plantes med et phyto, Tome XI, pp. 133-142, 1977.
19. Robert A.M.; Groult, N.; Six, C.; Robert, L. Etude de l’action
des oligomeres procyanidoliques sur des cellules mesenchymateuses en culture.
Ii l’attachment des fibres elastiques aux cellules. (Study of the effect
of procyanidolic oligomers on mesenchymal cells in culture. Ii attachment
of elastic fibers to the cells.) Pat Biol, (30)6:601-7, 1990.
20. Porter, Lawrence J., Wong Rosalind Y. Chan, Bock G. The molecular and
crystal structure of (+)-2,3-trans-3,4-trans-leucocyanidin [(2r,3s,+r)-(+)-3,3’,
4.4’, 5.7’-Hexahydroxyflavan] dihydrate, and comparison of its
heterocyclic ring conformation in solution and the solid state. Journal
of the Chemical Society; Perkin Transactions I 1985. pp. 1413-17.
21. Masquelier, J. Proanthocyanidins et radicaux libres. 1985.
22. Uchida, S., et al. Condensed tannins scavenge active oxygen free radicals.
Med Sci Res, (15) 1987. pp. 831-832.
23. Ariga, T. Radical scavenging action and its mode in procyanidins b-1
and b-3 from azuki beans to peroxyl radicals. Agric Biol Chem, 54(10) 1990.
pp. 2499-2504.
24. Da Silva, R., et. al. Radical scavenger capacity of different procyanidins
from grape seeds. Presented at a symposium, “Free radicals in biotechnology
and medicine.” Royal Society Of Chemistry, London January 1990, pp.
79-80.
25. Bauman, J., Wurm, G., Bruchhausen, F. “Hemmung der prostagladinsynthetase
durch flavonoide und phenolderivate im vergleich nit deren 02 radikalfangereigenschaften”
Arch Pharm, (Weinheim) 313 (1980) pp. 330-337.
26. Kidd, P.M. Phosphatidylserine: the nutrient that accelerates all brain
functions and counters Alzheimer’s disease: Keats Pub. 1998.
27. O'Brien, C., "Answers to ADD," Vitamin Retailer, March 2002.
28. Cenacchi T, et al. Cognitive decline in the elderly: A double-blind,
placebo-controlled multicenter study on efficacy of phosphatidylserine administration.
Aging, 5: 123–133, 1993.
29. Maggioni M, Picotti GB, Bondiolotti GP et al. Effects of phosphatidylserine
therapy in geriatric patients with depressive disorders. Acta Psychiatr
Scand. 81: 265–270, 1990.
30. Brambilla, F., Maggioni, M., Panerai, A.E., et al. Beta-endorphin concentration
in peripheral blood mononuclear cells of elderly depressed patients—effects
of phosphatidylserine therapy. Neuropsychobiology, 34: 18–21, 1996.
31. Monteleone P., Maj M., Beinat L., Natale M., Kemali, D. Blunting by
chronic phosphatidylserine administration of the stress-induced activation
of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharm,
43: 385–388, 1992.
32. Cenacchi T, et al., “Cognitive decline in the elderly: A double-blind,
placebo-controlled multicenter study on efficacy of phosphatidylserine administration.”
Aging, 5, 123-133, 1993
33. Funfgeld, E.W., Baggen, M., Nedwidek, P., Richstein, B., Mistlberger,
G. Double-blind study with phosphatidylserine (PS) in parkinsonian patients
with senile dementia of Alzheimer’s type (SDAT). Prog Clin Biol Res,
317:1235-46, 1989.
34. Le Bars, P.L., Katz, M.M., Berman, N., Itil, T.M., Freedman, A.M., Schatzberg,
F.A. A placebo-controlled, double-blind, randomized trial of an extract
of ginkgo biloba for dementia. Journal of the Amer Med Assoc, 278 (16):1327-32,
1997.
35. Waagepetersen, H.S., Sonnewald, U., Schousboe, A. The GABA paradox:
multiple roles as metabolite, neurotransmitter, and neurodifferentiative
agent. J Neurochem, 73:1335–42, 1999.
36. Goddard, A.W., Mason, G.F., Almai, A., Rothman, D.L., Behar, K.L., Petroff,
O.A.C., Charney, D.S., Krystal, J.H. Reductions in occipital cortex gaba
levels in panic disorder detected with h-magnetic resonance spectroscopy.
Arch Gen Psychiatry, 58:556-561, 2001.
37. Braverman, E., et al. The healing nutrients within: in facts, findings
and new research. Keats, 1987.
38. Cavagnini, F., et al. Effect of acute and repeated administration of
gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion
in man. Acta Endocrinol, 93:149–54, 1980.
39. Bhagavan, H.N., et al. The effect of pyridoxine hydrochloride on blood
serotonin and pyridoxal phosphate contents in hyperactive children. Pediatrics,
1975;55: 437-41.
40. ___. Along with riboflavin, vitamin B-6 deficiency has a primary role
in the cause of emotional disorder. British Journal of Psychiatry, 141(1982):271-272.
41. ___. Current data suggest that as many as 20 percent of medically cleared
population of outpatient depressives may suffer from a vitamin B-6 deficit.
The authors point out that nutrition, diet and vitamin levels have received
very little attention in the psychiatric literature. Biological Psychiatry,
9:4 (1984):613-6.
42. ___. Does depressive illness cause vitamin B-6 inadequacy, or vice-versa?
Nut Rep Int, 27 (Apr. 1993):867-873.
43. Martineau, J., et al. Vit. B6, magnesium, and combined B6-Mg: therapeutic
effects. Bio Psy, 20:467-78, 1985.
44. Dolphin, et al. (eds). Vitamin B6: pyridoxal phosphate. John Wiley &
Sons, 1986, chapt. 17.
45. Langseth, L., et al. Glucose tolerance and hyperkinesis. Food and Cosm
Toxicology, 16 Aug. 1977.
46. Bekaroglu, M., Aslan, Y., Gedik, Y., Deger, O., et al. Relationships
between serum free fatty acids and zinc, and attention deficit disorder:
a research note. J. Child Psychol. Psychiatry 1996 Fed; 37 (2):225-7.
47. Facino, R.M., et al. Free radical scavenging action and anti-enzyme
activities of procyanidines from vitis vinifera. A mechanism for their capillary
protective action. Arzneimittelforschung, 44: 592-601, 1994.
48. Kuttan, R., Donnelly, P.V., Di Ferrante, N. Collagen treated with catechin
becomes resistant to the action of mammalian collagenase. Experientia, 37:
221-223, 1981.
49. Masquelier, J. Procyanidolic oligomers. J Parums Cosm Arom, 95: 89-97,
1990.
50. Tixier, J.M., et al. Evidence by in vivo and in vitro studies that binding
of pycnogenols to elastin affects its rate of degradation by elastases.
Biochem Pharmacol, 33: 3933-3939, 1984.
51. Kakegawa, H., et al. Chem. Pharm. Bull. 33:5079, 1985.
52. Harmand, M.F., Blanquet, P. The fate of total flavanolic oligomers extracted
from ‘vitus vinifera l.’ in the rat. European Journal of Drug
Metabolism and Pharmaccokinetics. 1978, No. 1 pp. 15-30.
53. Delrieu, P., Ding J., Escande, B., Samain, D. Free-radical scavenging
activity of proanthocyanidolic oligomers encapsulated in glycospheres: an
in vivo and in vitro study. Cosmetology Department & S Biovectors, Ramonville
St. Agne France. pp. 1-9.
54. Meunier, M.T., Villie, F., et al. Inhibition of angiotensin i converting
enzyme by flavanolic compounds: in vitro and in vivo studies. Planta Medica,
May 26, 1986. pp. 12-15.
55. Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques
chez l’animal-oedenme de la patte. Sanofi Res Toul Cedex Fr, pp31-40.
56. Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques
chez l’animal-activite aniagoniste vis-a-vis des mediateurs de l’inflamation.
Sanofi Res Toul Cedex Fr, pp. 31-40.
57. Dubos, C., Durst, G., Hugonot, H. Evolution de la resistance capillaire,
spontanement ou artificiellement diminuee par l’action d’une substance
capillaro-toxique chez des personnes agees--action benefique d’un agnet
actif sur la micro-circulation: l’Endotelon. Inform. Therapeut. 1980.
pp. 302-305.
58. Dartenuc, J.Y., et al. Resistance capillaire en geriatrie etude d’un
microangioprotecteur-Endotelon. Bordeaux Med. 13:903-7, 1990.
59. Lagrue, G., Olivier-Martin, F., Grillot, A. “Etude des effets des
oligomeres du procyanidol sur las resistance capillaire dand l’hypertension
arterielle et certaines nephropathies.” Sen. Hosp. Paris 18-25 Septembre,
1981.
60. Beylot, C., Bioulac, P. Essai therapeutique d’un angioprotecteur
peripherique, l’Endotelon. Actualite Therapeutique Gaz. Med. de France
(87)22:2919-24, 1980.
61. Lesbre, F.X., Tigaud, J.D. Effect de l’Endotelon sur l’indice
de fragilite capillaire dan une population specifique: les sujets cirrhotiques.
Gaz. Med. de France, (90)24 1983.
62. Sarrat, L. Abord therapeutique des troubles fonctionnels des membres
inferieurs par un microangioprotecteur l’Endotelon. Bordeaux Med, 11:685-8,
1981.
63. Delacroix, P. Etude en double aveugle de l’Endotelon dans l’insuffisance
veineuse chronique. Therapeutique, la Revue de Medicine, (27-28) Sept. 1981.
pp. 1793-1802.
64. Thebaut, J.F, Thebaut, P., Vin, F. Etude de l’Endotelon dand les
manifestations fonctionnelles de l’insuffisance veineuse peripherique-resultats
d’une etude en double aveugle portant sur 92 patients.” Gazette
Medicale, (92)1, 1985. pp. 96-100.
65. Wegrowski, J., Robert, A.M., Maczar, M. Biochem. Pharmacol, (33)21.
1984. pp. 3491-3497.
66. Chang, W.C., Hsu, F.L. Inhibition of platelet aggregation and arachidonate
metabolism in platelets by procyanidins. Prostagland Leukotri Essent Fatty
Acids, 38:181-8, 1989.
67. Masquelier, J. Pycnogenols: recent advances in the therapeutical activity
of procyanidins. Supplement of Planta Medica, Journal of Medicinal Plant
Research and Journal of Natural Products, July 1980 pp. 243-256.
68. Henning, B., et al. Lipid peroxidation and endothelial cell injury:
implications in atherosclerosis. Free Rad Path & Med, (4)1988 pp. 99-106.
69. Masquelier, J. “Les procyanidols du vin leur role dans l’alcoolisme.”
pp. 88-93.
70. Gazave, J.M. “Notions recentes sur les capillaires” unpub.
bulletin from the Laboratoire De Physiologie Patholigie pp. 26-29.
71. Ruf, J.C. Wine and polyphenols related to platelet aggregation and atherothrombosis.
Office International Vigne et du Vin, Nutrition and Health Unit, Paris France;
Drugs under Experimental and Clinical Research (Switz.) 25/2-3 (125-131),
1999.
72. Blaszo, G. Gabor, M. Oedema-inhibiting effect of procyanidin. Acta Physiologica
Academiae Scientiarum Hungaricae, Tomus 56(2):235-240, 1980.
73. Tayau, M.F, LeFevre, G. Action du leucocyanidol sur l’hyalaluronidase.
Bull Soc Pharm Bordeaux, 95:132-136, 1956.
Lamy, M. Utilization des oligomeres procyanidoliques en gynecologie. Essai
Therapeutique Tomel (14) Sept. 2, 1981. pp. 1021-22.
74. Henriet, J.P “Une Etude Exemplaire Pour Un Phlebotrope: l’etude
EIVE.’ Unpub., pp. 77-83.
75. Pfister, A., Simon, M.T., Gazave, J.M. Sites de fixation des oligomeres
procyanidoliques dans la paroi des capillaires sanguins du poumon decobaye.
Acta Therapeutica (8) 1982. pp. 223-237.
76. Kuttan, R., Donnelly, P., Di Ferrante, N. “Collagen treated with
(+) -catechin becomes resistant to the action of mammalian collagenase.”
Laboratory of Connective Tissue Research, Dept. of Biochem. Baylor Col.
of Med., Houston TX. 28, May, 1980.
77. Gendre, P., Laparra, J., Barraud, E. “Effect protecteur des oligomeres
procyanidoliques sur le lathyrisme experimental chez le rat.” Ann.
Pharm. Francaises, (43)1, 1985 pp. 61-73.
78. Corbe, C., Boissin, J.P., Siou, A. Light vision and chorioretinal circulation.
Study of the effect of procyanidolic oligomer (Endotelon). Jn. Fr. Opthalmol,
(11)5:453-460, 1988.
79. Boissin, J.P., Corbe C., Siou, A. Chorioretinal circulation and dazzling:
use of procyanidol oligomers (Endotelon). Bull Soc Ophtalmol Fr, 88(2):173-4,
177-9, 1988.
80. Proto, F. et al. Electrophysical study of vitis vinifera procyanoside
oligomers effects on retinal function in myopic subjects. Ann Ott Clin Ocul,
114:85-93, 1988.
81. Saracco, J.B., Estachy, G.M. Etude d l’Endotelon en opthalmologie.
Gaz Med de France, 88:2035-2038, 1981.
82. Scharrer, A., Ober, M. Anthocyanosides in the treatment of retinopathies.
Klin Monatsbl Augenheilkd, 178:386-389, 1981.
83. Corbe, C., et al. Microangiopathy of the retina. J. Fr. Opthalmol, 11:453,
1988.
84. Verin, M.M., Vildy, A., Maurin, J.F., Retinopathies et O.P.C. Bordeaux
Medicale, (16)11. pp. 1467-74, 1978.
85. Soyeux, A. et al. Endotelon. Diabetic retinopathy and hemorheology.
Bull Soc Ophtalmol Fr. 87(12):1441-4, 1987.
86. Fromantin, M. “Les oligomeres procyanidoliques dans le traitement
de la fragilite capillaire et de la retinopathie chez les diabetiques. A
propos de 26 cas.” Med Int, 16(11):432-434, Nov. 1981.
87. Arne, J.L. Contribution a l’etude des oligomeres procyanidoliques:
Endotelon, dans la retinopathie diabetique (a propos de 30 observations).
Gaz. Med. de France, Vol. 89, No. 30, Oct. 8, 1982.
88. Baruch, J. Effect of Endotelon in postoperative edema. Results of a
double-blind study versus placebo in 32 female patients. Ann Chir Plast
Esthet 29(4):393-5, 1984.
89. Rao, C.N. et al. Influence of bioflavonoids on the collagen metabolism
in rats with adjuvantinduced arthritis. Ital J Biochem. 30:54-62, 1981.
90. Gabor, M. Pharmacologic effects of flavonoids on blood vessels. Angiologica,
9:355-374, 1972.
91. Havsteen, B. Flavonoids, a class of natural products of high pharmacological
potency. Biochem Pharmacol, 32:1141-48, 1983.
92. Reimann, H.J., Lorenz, W., Fischer, M., Frölich, R., Meyer, H.J.
Berkhauser Verlag, Vol. 7/1, Univ. of Marburg/Lahn, Ger., 1977.
93. Masquelier, J. Action protectrice du vin sur l’ulcere gastrique.
Resultats, p. 61.
94. Amella, M., et al. Inhibition of mast cell histamine release by flavonoids
and bioflavonoids. Planta Medica, 5116-20, 1985.
95. Packer, L., et al. The antioxidant miracle: your complete plan. John
Wiley & Sons, Inc., 1999.
96. Shaw, R. How [Australian] PycnoGenol [MASQUELIER’s®] Helps
Sports People.
97. Masquelier, J. Procyanidolic oligomers (leucocyanidins). Parfums Cosmet
Arom 95:89-97, 1990.
98. Pecking, A., Desprez-Curely, J.P., Megret, G. Oligomers procyanidoliques
(Endotelon) dans le traitement des lymphoedemes post-therepeutiques de members
superieurs. Symposium Satellite, Congres International d’Angiologie,
Toulouse, France, 4-7 Oct. 1989.
99. Fahey, T.D., Pearl M. Hormonal effects of phosphatidylserine during
2 weeks of intense training. Abstract submitted to national meeting of the
Amer College of Sports Medicine, June 1998.
100. Monteleone, P., Maj, M., Beinat, L., Natale, M., Kemali, D. Blunting
by chronic phosphatidylserine administration of the stress-induced activation
of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharm
43: 385–388, 1992.
101. Fahey, T.D., et al. The hormonal and perceptive effects of phosphatidylserine
administration during two weeks of resistive exercise-induced overtraining.
Bio of Sport 15(3):135-44, 1998.
102. Laparra, J., Michaud, J. Masquelier, J. Action des oligomeres procyanidoliques
sur le cobaye carence en vitamin c. Tavaux Originaux, University of Bordeaux,
1976.
103. Masquelier, J. Action comparee de divers facteurs vitaminiques p sur
l’oxydation de l’acide ascorbique par les ions cuivriques. Bull.
de la Societe de Chimie Biologique XXXIII (3-4) 1951. pp. 302-304.
104. Masquelier, J. Action comparee de divers facteurs vitaminiques p sur
l’acide ascorbique-oxydase. Bull. de la Societe de Chimie Biologique
XXXIII (3,4) 1951. pp.304-306
105. Kakegawa, H., Matsumoto, H., Endo, K., Satoh, T., Nonaka, G., Mishioka,
I. “Inhibitory effects of tannins on hyaluronidase activation and on
the degranulation from rat mesentery mast cells.” Chem. Pharm. Bull.
33(11)1985. 5079-5082.
106. Reiman, H.J., Lorenz, M., Fischer, R., Frolich, H., Meyer, J. “Histamine
and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress
ulcer formulation by (+)-catechin, an inhibitor of specific histidine decarboxylase
in vitro.” Dirkhauser Verlag,Vol. 7/1, 1977.
107. Pariente, J.J. Parientl-Amsellem, J. “Les oedemes post-traumatoqies
chez le sportif: essai controle de l’Endothelon.” Actualite Therapeutique
90(3) 2/11 1983 pp. 231-235.
108. Masquelier, J., et al. “Flavonoids et Pycnogenols” Int J
Vit Nut Res, (49)3:307-311, 1979.
109. Yu, C. L. et al. Mutagenicity of proanthocyanidins. Food Chem. Toxicol.
25(2):135-9, 1987.
110. Pantaleoni, G.C., Quaglino, D. Univerisity of Aquila Pharmacol-Toxicologica
Report, 1971.
111. Laparra, J., et al., Acta Therapeutica, 4:233, 1978.
112. Volkner, Wolfgang Muller, Ewald, Micronucleus assay in bone marrow
cells of the mouse with Pycnogenol. Cytotest Cell Research GmbH & Co.,
projects 143010 & 143021; Feb. 1989.
113. Acute and chronic toxicity tests. International Bio-Research, Inc.,
Hanover, Germany, 1967-1971.
114. Dumon, M., Michaud, J., Masquelier, J. Proanthocyanidin content in
vegetable extracts to be used in the preparation of medicines. Bull. Soc.
Pharm. Bordeaux, 129:51-65, 1990.
115. Carper, J., Miracle Cures : Dramatic New Scientific Discoveries Revealing
the Healing Powers of Herbs, Vitamins, and Other Natural Remedies, HarperCollins
Publishers, 1998.
116. Philpott, W.H., Kalita, D.K., et al., Brain Allergies: The Psychonutrient
Connection, Keats Publishing, 1980.
117. Journal of the American Medical Association report on meeting of experts
on the subject of food and behavior. Conclusions from this conference were
summarized as follows: "Dietary pharmacology is no longer at the fringe
of medicine ... Foods do affect behavior. Foods do affect the brain."
JAMA 254:4, Dec. 27, 1985.
118. Wender, E.H., Solanto, M.V., "Effects of sugar on aggressive and
inattentive behavior in children with attention deficit disorder with hyperactivity
and normal children." Pediatrics, 1991 Nov; 88 (5): 960-6.
119. Kaneko, M., et al., "Hypothalamic-putuitary-adrenal axis function
in children with attention deficit hyperactivity disorder." 120. The
Journal of Autism and Developmental Disorders, 1993 Mar; 23 (1): 59-65.
121. Vatz, R.E., professor at Towson State University, and Weinberg, L.S.,
of the University of Pittsburg, "Attention Deficit Delirium,"
Wall Street Journal, July 27, 1994.
122. Physicians Desk Reference® (PDR®), 53rd Edition, Medical Economics
Company.
123. Breggin P.R., Director, Int Cntr for the Study of Psychiatry and Psychology;
Testimony Before the Subcommittee on Oversight and Investigations Committee
on Education and the Workforce U.S. House of Representatives, September
29, 2000.
124. Breggin, P.R., "Psychostimulants in the treatment of children
diagnosed with ADHD: Risks and mechanism of action," International
Journal of Risk and Safety in Medicine, 12, 3-35, 1999.
125. Lambert, N., "Stimulant treatment as a risk factor for nicotine
use and substance abuse," Program and Abstracts, 191-8, 1998. NIH Consensus
Development Conference Diagnosis and Treatment of Attention Deficit Hyperactivity
Disorder. November 16-18, 1998. William H. Natcher Conference Center. National
Institutes of Health. Bethesda, Maryland.
126. American Academy of Pediatrics, "Practice guideline: Diagnosis
and evaluation of a child with attention-deficit/hyperactivity disorder,"
Pediatrics, 105, 1158-70, 2000.
127. Hallowell, E.M., Ratey, J.J., "Driven to Distraction: Recognizing
and Coping With Attention Deficit Disorder," Simon & Schuster,
1995.
128. Campbell, L.R., and Cohen, M., "Management of Attention Deficit
Hyperactivity Disorder: A Continuing Dilemma for Physicians and Educators,"
Clinical Pediatrics, March, 1990, 29: 191-3.
129. Balch, J.F., "The Super Antioxidants - Why They Will Change The
Face of Healthcare in the 21st Century," M. Evans and Company, Inc.,
1998.
130. Passwater, R., Avery Publishing.
131. Weintraub, S., "Natural Treatments for ADD and Hyperactivity,"
Woodland Publishing, 1997.
132. Diller, L.H., "Running On Ritalin: A Physician Reflects on Children,
Society, and Performance in a Pill," Bantam Books, 1998, 42-43.
133. Reichenberg-Ullman, J., Ullman, R., "Ritalin Free Kids: Safe and
Effective Homeopathic Medicine for ADD and Other Behaviorial and Learning
Problems," Prima Health Publishing, 1996.
134. "Ritalin Finding Its Way Into the Schoolyard," Seattle Times,
February 9, 1996; idem.
135. "A Risky Rx for Fun," Newsweek, October 30, 1995, 74; idem.
136. Adesman, A.R., Wender, E.H. "Helping the Hyperactive Child,"
Patient Care, March 30, 1992, 96-116.
137. Wender, P.H., Attention Deficit Disorder in Adults, New York/Oxford:
Oxford University Press, 1995, 166.
138. Swanson, J.M., et al., "Effect of Stimulant Medication on Children
with Attention Deficit Disorder: A Review of Reviews," Exceptional
Children, 60, 1993: 154-162.
139. Bhagavan, H.N., Coleman, M., Coursin, D.B."The effect of pyridoxine
hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive
children." Pediatrics 1975;55: 437-41.
140. Martineau, J., Barthelemy, C., Garreau, B., Lelord, G. "Vitamin
B6, magnesium, and combined B6-Mg: therapeutic effects in childhood autism."
Biological Psychiatry 1985;20:467-78
141. Dolphin, et al (eds). Vitamin B6: Pyridoxal Phosphate. Toronto: John
Wiley & Sons, 1986, chapter 17.
142. The International Nutrition Company Special Report: "Masquelier's
Original OPCs and 10 grape seed extracts: An Independent State of the Art
Comparative Analysis," November 1997.
143. Vogel, J., "A Stress Test for Children; Is Your 'Problem Child's'
Problem Nutrition?", Keats Publishing, 1983.
144. Langseth, L., Dowd, J., "Glucose tolerance and hyperkinesis,"
Food and Cosmetic Toxicology, 16 August 1977.
145. Monkeberg, F., Schrimshaw, N.S., Gordon, J.E., et al., "Effect
of early marasmic malnutrition on subsequent physical and psychological
development," Malnutrition, Learning and Behavoir, Cambridge, Mass.:
MIT Press, 1968.
146. Crook, W.G.,"Can a What a Child Eats Make Him Dull, Stupid or
Hyperactive?", Journal of Learning Disabilities, 13:53-58, 1980.
147. Egger, J., et al., "Controlled Trial of oligoantigenic treatment
in the hyperkinetic syndrome, Lancet, 1985 Mar 9: 540-5.
148. Kidd, P., "Phospholipids: life's buildling blocks." Vitamin
Retailer, Oct. 2002.
149. Benton, D, et al., Nutr Neurosci 2001;4;169.
150. Kidd, P., Total Health 2002;24: Resource Guide, May-June.
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