Probenecid
Probenecid (proe-BEN-e-sid) is
used in the treatment of chronic gout or gouty arthritis. These conditions
are caused by too much uric acid in the blood. The medicine works by
removing the extra uric acid from the body. Probenecid does not cure gout,
but after you have been taking it for a few months it will help prevent gout
attacks. This medicine will help prevent gout attacks only as long as you
continue to take it.
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Probenecid Side Effects
as reported by "The PDR® Family Guide To Prescription Drugs®" |
Proper Use of This Medicine
If probenecid upsets your stomach, it may
be taken with food. If this does not work, an antacid may be taken. If
stomach upset (nausea, vomiting, or loss of appetite) continues, check
with your doctor.
For patients taking probenecid for gout :
- After you begin to take probenecid, gout
attacks may continue to occur for a while. However, if you take this
medicine regularly as directed by your doctor, the attacks will
gradually become less frequent and less painful than before. After you
have been taking probenecid for several months, they may stop
completely.
- This medicine will help prevent gout
attacks but it will not relieve an attack that has already started.
Even if you take another medicine for gout attacks, continue to take
this medicine also . If you have any questions about this, check with
your doctor.
For patients taking probenecid for gout or
to help remove uric acid from the body :
- When you first begin taking probenecid,
the amount of uric acid in the kidneys is greatly increased. This may
cause kidney stones or other kidney problems in some people. To help
prevent this, your doctor may want you to drink at least 10 to 12 full
glasses (8 ounces each) of fluids each day, or to take another
medicine to make your urine less acid. It is important that you follow
your doctor's instructions very carefully.
Precautions While Using This Medicine
If you will be taking probenecid for more
than a few weeks, your doctor should check your progress at regular
visits.
Before you have any medical tests, tell the
person in charge that you are taking this medicine. The results of some
tests may be affected by probenecid.
For diabetic patients :
- Probenecid may cause false test results
with copper sulfate urine sugar tests (Clinitest[reg ]), but not with
glucose enzymatic urine sugar tests (Clinistix[reg ]). If you have any
questions about this, check with your health care professional.
For patients taking probenecid for gout or
to help remove uric acid from the body :
- Taking aspirin or other salicylates may
lessen the effects of probenecid. This will depend on the dose of
aspirin or other salicylate that you take, and on how often you take
it. Also, drinking too much alcohol may increase the amount of uric
acid in the blood and lessen the effects of this medicine. Therefore,
do not take aspirin or other salicylates or drink alcoholic beverages
while taking this medicine , unless you have first checked with your
doctor.
Probenecid Side Effects
Along with its needed effects, a medicine
may cause some unwanted effects. Although not all of these side effects
may occur, if they do occur they may need medical attention.
The following side effects may mean that
you are having an allergic reaction to this medicine. Check with your
doctor immediately if any of the following side effects occur:
Rare
Fast or irregular breathing; puffiness or
swellings of the eyelids or around the eyes; shortness of breath,
troubled breathing, tightness in chest, or wheezing; changes in the skin
color of the face occurring together with any of the other side effects
listed here; or skin rash, hives, or itching occurring together with any
of the other side effects listed here
Also, check with your doctor as soon as
possible if any of the following side effects occur:
Less common
Bloody urine; difficult or painful
urination; lower back or side pain (especially if severe or sharp); skin
rash, hives, or itching (occurring without other signs of an allergic
reaction)
Rare
Cloudy urine; cough or hoarseness; fast
or irregular breathing; fever; pain in back and/or ribs; sores, ulcers,
or white spots on lips or in mouth; sore throat and fever with or
without chills; sudden decrease in the amount of urine; swelling of
face, fingers, feet, and/or lower legs; swollen and/or painful glands;
unusual bleeding or bruising; unusual tiredness or weakness; yellow eyes
or skin; weight gain
Other side effects may occur that usually
do not need medical attention. These side effects may go away during
treatment as your body adjusts to the medicine. However, check with your
doctor if any of the following side effects continue or are bothersome:
More common
Headache; joint pain, redness, or
swelling; loss of appetite; nausea or vomiting (mild)
Less common
Dizziness; flushing or redness of face
(occurring without any signs of an allergic reaction); frequent urge to
urinate; sore gums
Other side effects not listed above may
also occur in some patients. If you notice any other effects, check with
your doctor.
References: (1) Physicians
Desk Reference (PDR) 1997 Edition
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