| Rebif
- (interferon beta-1a)
Is used in the treatment of multiple
sclerosis.
Read about an natural
supplement recommended by
many health care professionals.
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Side Effects
and Warnings
|
Multiple Sclerosis is thought to be an
autoimmune disease. Your immune system attacks the myelin sheath that surrounds nerve
cells. This damage leads to muscle weakness, paralysis, poor coordination, balance
problems, fatigue, and possible blindness.
Rebif (interferon beta-1a) has been approved by the FDA for the treatment of relapsing forms of multiple sclerosis.
Rebif has been shown to decrease the frequency of clinical exacerbations and delay the accumulation of physical disability in patients with MS.
The recommended dose of the product is 44 mcg three times per week to be administered by subcutaneous injection.
Rebif is supplied in single-use, pre-filled syringes.
Rebif previously was approved in Europe in 1998 and currently is registered for use in over 70 countries.
More Common Side Effects
Flu-like symptoms
Abdominal pain
Depression
Elevation of liver enzymes
Blood cell abnormalities
Depression and suicidal indeation have been reported to occur more frequently in patients
being treated with interferon compounds, including Rebif.
Mechanism of action
Interferons are a family of naturally occurring proteins that
are produced by eukaryotic cells in response to viral infection and other biological inducers.
Interferons possess immunomodulatory, antiviral and antiproliferative biological activities.
They exert their biological effects by binding to specific receptors on the surface of cells…
Type 1 interferons have considerably overlapping but also distinct biological activities.
Interferon beta is produced naturally by various cell types including fibroblasts and macrophages.
Binding of interferon beta to its receptors initiates a complex cascade of intracellular events that
leads to the expression of numerous interferon-induced gene products and markers,
including 2’,5’-oligoadenylate synthetase, beta 2-microglubin and
neopterin, which may mediate some of the biological activities.
The specific interfereon-induced proteins and mechanisms by which interferon beta-1a exterts its effects
in multiple sclerosis have not been fully defined. (from Rebif package insert)
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