Sulfinpyrazone
Sulfinpyrazone (sul-fin-PEER-a-zone ) is used in the
treatment of chronic gout (gouty arthritis), which is caused by too much
uric acid in the blood. The medicine works by removing the extra uric acid
from the body. Sulfinpyrazone does not cure gout, but after you have been
taking it for a few months it may help prevent gout attacks. This medicine
will help prevent gout attacks only as long as you continue to take it.
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Sulfinpyrazone Side Effects
as reported by "The PDR® Family Guide To Prescription Drugs®" |
Proper Use of This Medicine
If sulfinpyrazone upsets your stomach, it may be taken with food
In order for sulfinpyrazone to help you, it must be taken regularly
as ordered by your doctor
When you first begin taking sulfinpyrazone, the amount of uric acid in
the kidneys is greatly increased. This may cause kidney stones in some
people. To help prevent this, your doctor may want you to drink at least
10 to 12 full glasses (8 ounces each) of fluids each day, or to take
another medicine to make your urine less acid. It is important that you
follow your doctor's instructions very carefully.
For patients taking sulfinpyrazone for gout:
- After you begin to take sulfinpyrazone, gout attacks may continue to
occur for a while. However, if you take this medicine regularly as
directed by your doctor, the attacks will gradually become less
frequent and less painful. After you have been taking sulfinpyrazone
for several months, they may stop completely.
- Sulfinpyrazone helps to prevent gout attacks. It will not relieve an
attack that has already started. Even if you take another medicine
for gout attacks, continue to take this medicine also.
Precautions While Using This Medicine
Your doctor should check your progress at regular visits to make sure
that this medicine does not cause unwanted effects.
Before you have any medical tests, tell the person in charge that you
are taking this medicine. The results of some tests may be affected by
sulfinpyrazone.
For patients taking sulfinpyrazone for gout or to help remove uric
acid from the body:
- Taking aspirin or other salicylates may lessen the effects of
sulfinpyrazone. This will depend on the dose of aspirin or other
salicylate that you take, and on how often you take it. Also, drinking
too much alcohol may increase the amount of uric acid in the blood and
lessen the effects of sulfinpyrazone. Therefore, do not take
aspirin or other salicylates or drink alcoholic beverages while taking
this medicine, unless you have first checked with your doctor.
Sulfinpyrazone Side Effects
Along with its needed effects, a medicine may cause some unwanted
effects. Although not all of these side effects may occur, if they do
occur they may need medical attention.
Check with your doctor immediately if any of the following side
effects occur:
Rare
Shortness of breath, troubled breathing, tightness in chest, and/or
wheezing; sores, ulcers, or white spots on lips or in mouth;
sore throat and fever with or without chills; swollen and/or
painful glands; unusual bleeding or bruising
Symptoms of overdose
Clumsiness or unsteadiness; convulsions (seizures);
diarrhea; nausea or vomiting (severe or continuing);
stomach pain (severe or continuing); difficulty in breathing
Also, check with your doctor as soon as possible if any of the
following side effects occur:
More common
Lower back and/or side pain; painful urination (possibly with
blood)
Less common
Rare
Bloody or black, tarry stools; fever ; increased blood
pressure; pinpoint red spots on skin; sudden decrease in
amount of urine; swelling of face, fingers, feet, and/or lower
legs; unusual tiredness or weakness; vomiting of blood or
material that looks like coffee grounds ; weight gain
Other side effects may occur that usually do not need medical
attention. These side effects may go away during treatment as your body
adjusts to the medicine. However, check with your doctor if any of the
following side effects continue or are bothersome:
More common
Joint pain, redness, and/or swelling; nausea or vomiting;
stomach pain
Other side effects not listed above may also occur in some patients. If
you notice any other effects, check with your doctor.
References: (1) Physicians
Desk Reference (PDR) 1997 Edition
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