Zyloprim
Zyloprim is used in the treatment of many symptoms of gout, including
acute attacks, tophi (collection of uric acid crystals in the tissues,
especially around joints), joint destruction, and uric acid stones. Gout
is a form of arthritis characterized by increased blood levels of uric
acid. Zyloprim works by reducing uric acid production in the body, thus
preventing crystals from forming.
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Side Effects
as reported by "The PDR® Family Guide To Prescription Drugs®" |
Side Effects
Side effects cannot be anticipated. If any
develop or change in intensity, inform your doctor as soon as possible.
Only your doctor can determine if it is safe for you to continue taking
Zyloprim.
Because a skin reaction, the most common
side effect of Zyloprim, may occasionally become severe or even fatal, you
should stop taking Zyloprim if you notice even the beginnings of a rash.
Such a rash may be itchy or scaly or may make your skin peel off in
sheets; it may be accompanied by chills and fever, aching joints, or
jaundice.
- More common side effects may include:
Acute attack of gout, diarrhea, nausea, rash
- Less common or rare side effects may
include:
Abdominal pain, bruising, chills, fever, hair loss, headache,
hepatitis, hives, indigestion, itching, joint pain, kidney failure,
loosening of nails, muscle disease, nosebleed, rare skin condition
characterized by severe blisters and bleeding on the lips, eyes, or
nose, reddish-brown or purplish spots on skin, skin inflammation or
peeling, sleepiness, stomach inflammation, taste loss or change,
tingling or pins and needles, unusual bleeding, vomiting, yellowing of
skin and eyes
Special warnings about this
medication
If you notice a rash or other signs of an allergic reaction, stop
taking Zyloprim immediately and consult your doctor. In some people, a
Zyloprim-induced rash may lead to a serious skin disease, generalized
inflammation of a blood or lymph vessel, irreversible liver damage, or
even death.
You may experience acute attacks of gout
more often in the early stages of Zyloprim therapy, even when normal uric
acid levels have been attained. These attacks will become shorter and less
severe after several months of therapy.
A kidney problem may turn a normal dose of
Zyloprim into an overdose. If you have a kidney disease, or a condition
such as diabetes or high blood pressure that may affect your kidneys, your
doctor should prescribe Zyloprim cautiously and order periodic blood and
urine tests to assess your kidney function.
Because Zyloprim may make you drowsy, do
not drive or perform hazardous tasks until you know how the medication
affects you.
It may be 2 to 6 weeks before you see any
results from this medication.
Possible food and drug interactions
when taking this medication
If Zyloprim is taken with certain other
drugs, the effects of either could be increased, decreased, or altered. It
is especially important to check with your doctor before combining
Zyloprim with the following:
Amoxicillin (Amoxil, Trimox, Wymox)
Ampicillin (Omnipen, Principen)
Azathioprine (Imuran)
Blood thinners such as Coumadin
Cyclosporine (Sandimmune, Neoral)
Drugs for diabetes, such as Diabinese and Orinase
Mercaptopurine (Purinethol)
Probenecid (Benemid, ColBENEMID)
Sulfinpyrazone (Anturane)
Theophylline (Theo-Dur, Slo-Phyllin, and others)
Thiazide diuretics such as HydroDIURIL, Diuril, and others
Vitamin C
References: (1) Physicians
Desk Reference (PDR) 1997 Edition
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